As Oxford MediStress continues to expand its team, we welcome Yifei Cao and Xiaomeng Li to the team

An article has been published in the journal, Frontiers in Veterinary Science, which reviews many studies using the LCC test and technique.

https://www.frontiersin.org/articles/10.3389/fvets.2019.00105/full

Huber, N., Marasco, V., Painer, J., Vetter, S. G., Göritz, F., Kaczensky, P., & Walzer, C. (2019).

Leukocyte Coping Capacity: An Integrative Parameter for Wildlife Welfare Within Conservation Interventions.

Frontiers in veterinary science, 6, 105. doi:10.3389/fvets.2019.00105

Copyright © 2019 Huber, Marasco, Painer, Vetter, Göritz, Kaczensky and Walzer.

Table 1 from this paper both provides and is entitled “An overview of studies inferring LCC as a valid proxy to assess stress and welfare in animals”

Open pdf  Animal Welfare Studies And References

“Of Street Mice and Men: A Radical Approach to Old Problems” published in Stress and Health: New Research, Chapter 3, pages 61 – 79, editor Kimberly V Oxington Nova Science Publications.\r\n\r\nAbstract: The tremendous destructive capabilities of reactive oxygen species in stress related disorders has become apparent only recently, although in early historical times the ancients may have been aware of the devastating power of stress on well-being. This chapter explores ancient myths and modern techniques surrounding stress-induced immunosuppression in species as diverse as mice and humans, investigating techniques and mechanisms, and speculating on possible therapeutic interventions.\r\n\r\nPreview the article here.

This study demonstrates how immune responsiveness, known to be influenced by psychological stress, can be used to assess changes in mental workload. Healthy male and female subjects provided capillary blood samples before and after completing the same, basic, driver-related tasks followed by a simple manoeuvre in two unfamiliar motor vehicles.

Using the Leukocyte Coping Capacity (LCC) test kit, the ability of leukocytes to produce reactive oxygen species in vitro was assessed. Significant post-stressor changes in leukocyte activity were demonstrated between treatment groups. These findings add weight to the proposition that leukocyte activation is a useful quantitative measure of psychological stress and mental loading in humans. This study demonstrates the diagnostic ability of LCC for use during ergonomic evaluation.

SHELTON-RAYNER G, MIAN R, CHANDLER S, ROBERTSON D, MACDONALD DW (2012) Leukocyte responsiveness, a quantitative assay for subjective mental workload. Int J Industrial Ergonomics 42, 25-33.

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The capability of drivers to accomplish basic tasks utilizing differing sensory modalities while maintaining lane discipline within a computer-simulated environment was assessed. Subjects provided capillary blood samples before and after using three human–machine interface designs—touch-screen, voice control, and multimodal.

Using the Leukocyte Coping Capacity test kit, the ability of leukocytes to produce reactive oxygen species in vitro was assessed. Significant post-stressor changes in leukocyte activity of varying magnitude were observed following the use of all interfaces; with the multimodal interface provoking the most pronounced response and voice control the least. Results support the proposition for using immune responsiveness as a means for quantifying psychological stress.

SHELTON-RAYNER G, MIAN R, CHANDLER S, ROBERTSON D, MACDONALD DW (2011) Quantitative physiological assessment of mental loading via altered immune functioning following interaction with differing automotive interface technologies. International Journal of Human-Computer Interaction 27 (9), 900–919.

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